https://arpaialab.nyc/home daily 1.0 2020-10-20 https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1477591352364-OEAXCF2Q0ELPKUMZYFIY/GWS_website+cover+%281%29.jpg Home https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1483555265601-S2LI1TAZBUD3X469B17M/image-asset.png Home https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1483135522388-5890D2AMBHDAI3JT7W6W/skybridges.jpeg Home https://arpaialab.nyc/contactus daily 0.75 2018-05-05 https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1483558049917-GI0AN81XTFK7EEPS75UP/IMG_0181.jpg Contact Us https://arpaialab.nyc/positions daily 0.75 2025-07-01 https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1483554552635-RBME7NT6E4753UXV8AK9/IMG_0202.jpg Positions https://arpaialab.nyc/publications daily 0.75 2026-09-18 https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1483050988568-H8O1WTUD3XHJAP6RZBML/IMG_0088.jpg Publications https://arpaialab.nyc/people daily 0.75 2025-04-01 https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1526318206658-PVRMXT9REFF3U8OBJDTK/160824_17-57-17_5DSR1810.0.jpg People https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1526568499831-U2DFSI5JUOM8J8V76LR5/IMG_0633.jpg People https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1621274169148-MHT1E3XEHUXFTEVNJW8Y/Mathieu_edited2.png People https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/7700c304-2458-445e-9c66-e2db80e01aad/Unknown-1.jpg People - 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Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/745fada0-d8de-4d38-a868-805d6a63d94e/IMG_4688.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/9ce14684-5087-438e-9199-97bbcc17c576/Unknown.jpg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/9d6539a7-c9ca-4d00-b50e-1e5fabebfd3a/renzo.jpg People https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1623096437583-RQ8XKH21ZCTT2QET6G0Y/Unknown.jpeg People https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1526317233616-84A6385VQ2MH857V8U09/IMG_1341+%281%29+copy+2.jpg People https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1526319405964-WRF87DSULJQM8ZPBCMEQ/IMG_1278+copy.jpg People https://arpaialab.nyc/research daily 0.75 2026-10-03 https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1483557971112-OZR4T1QYGCLSHER9N7YI/IMG_0175.jpg Research https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790977673795-HK118VVVSUNH55VM775N/nature-outlook-2026-drug-delivery-illustration.gif Research - SPECIAL DELIVERY: BACTERIAL COURIERS ARE SMUGGLING DRUGS INTO CANCERS Bacterial couriers smuggling drugs into tumors. Illustration: Julia Specht, Roar Artists, for Nature. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790977628923-9G5NXQGXH9VOQDI9190G/kaiser-jem-2023-cover-slide.jpg Research - TREGS AT SITES OF VIRAL LUNG INFECTION Regulatory T cells (green) at sites of influenza infection in mouse lung. Cover, J Exp Med, March 2023. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790977644801-I7ZBARZ98FRU38TFL2I7/ringham-natimmunol-2026-lung-tumor-slide.jpg Research - TREGS AND imCAFS IN LUNG TUMORS Tregs (green) localize with CHL1⁺ fibroblasts (red) in mouse lung tumors. Ringham et al., Nat Immunol 2026. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790977636653-HQXUZPFUWPYYQ29KJ0YE/chowdhury-natmed-2019-cover-slide.jpg Research - PROGRAMMABLE BACTERIA FIGHT TUMORS Engineered bacteria as nesting dolls making immunotherapy inside tumors. Cover, Nat Med, July 2019. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790978126990-GQKJQSI6GCBD6492LVWF/kaiser-jem-2023-organoids-slide.jpg Research - ALVEOLAR ORGANOIDS Alveolar organoids grown with sorted lung mesenchymal cells. pro-SPC (AT2 cells, red), RAGE (AT1 cells, green), and DAPI (nuclei, blue). Kaiser et al., J Exp Med 2023. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790977661956-EQCEOY3WHGU80I7FV0MI/rouanne-scitranslmed-2026-bladder-ultrasound-slide.jpg Research - IMAGING BLADDER TUMORS Ultrasound of a mouse bladder tumor before treatment. Rouanne et al., Sci Transl Med 2026. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/c48d2701-477a-4fb7-b9e7-baac5518de1e/loffredo-jem-2024-review-schematic.png Research - Make it stand out Regulatory T cells promote repair both by dampening inflammation (A, top) and by releasing mediators that act directly on tissue-resident non-immune cells (A, bottom). These mediators are sensed by tissue-specific structural cells, which generate context-specific repair programs (B). Reproduced from Loffredo et al., J Exp Med 2024;221:e20231244 [Review], under CC BY 4.0. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790984663038-G9T0Q8HNXDSFAHK23S9N/yang-scitranslmed-2026-schematic-slide.png Research - COMBINATION CHEMOIMMUNOTHERAPY WITH ENGINEERED PROBIOTICS Tumor-targeting E. coli Nissle release cytosine deaminase, an IL-15 fusion protein, and a PD-L1 nanobody. Yang et al., Sci Transl Med 2026. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790984693876-GMGBL8GWJJSJTC474LIU/redenti-nature-2024-schematic-slide.png Research - ENGINEERED PROBIOTIC NEOANTIGEN VACCINES Engineered probiotic E. coli Nissle 1917 deliver tumor neoantigens as a personalized vaccine. Redenti et al., Nature 2024. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790984255754-C6WIKUDF7XHTOQ1KZOGJ/savage-sciadv-2023-schematic-slide.png Research - RECRUITING IMMUNE CELLS WITH ENGINEERED PROBIOTICS Probiotic bacteria release CXCL16 and CCL20 to recruit T cells and dendritic cells into tumors. Savage et al., Sci Adv 2023. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/1790984268004-PMOXOVEAAI98FEHH3NTZ/chowdhury-natmed-2019-schematic-slide.png Research - BACTERIA THAT LYSE INSIDE TUMORS Engineered bacteria lyse at a quorum and release an anti-CD47 nanobody inside tumors. Chowdhury et al., Nat Med 2019. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/70953706-2e5a-49d9-8ab3-028b03c2e17f/rankin-cellrep-2023-graphical-abstract.png Research - Make it stand out Dietary tryptophan supports microbial tryptophan metabolites that signal through AhR to keep RORγt⁺ Treg cells in homeostasis. Without tryptophan, the microbiome is altered, metabolites and AhR signaling decrease, and RORγt⁺ Treg cells expand. Graphical abstract from Rankin et al., Cell Rep 2023;42:112135, under CC BY 4.0. https://images.squarespace-cdn.com/content/v1/57e5501a893fc0d23d38754a/59931d82-d42c-4725-84cc-b4c20afa15e2/nature-outlook-2026-drug-delivery-illustration.gif Research - Make it stand out Whatever it is, the way you tell your story online can make all the difference.